Fibrin-mediated lentivirus gene transfer: Implications for lentivirus microarrays

Lentivirus-mediated Gene Expression

Adherens Junction Formation Inhibits Lentivirus Entry and Gene Transfer

Although cellular signaling pathways that affect lentivirus infection have been investigated, the role of cell-cell interactions in lentiviral gene delivery remains elusive. In the course of our studies we observed that lentiviral gene transfer was a strong function of the position of epithelial cells within colonies. While peripheral cells were transduced efficiently, cells in the center of co...

A transitional endogenous lentivirus from the genome of a basal primate and implications for lentivirus evolution.

Lentiviruses chronically infect a broad range of mammalian species and have been transmitted from primates to humans, giving rise to multiple outbreaks of HIV infection over the past century. Although the circumstances surrounding these recent zoonoses are becoming clearer, the nature and timescale of interaction between lentiviruses and primates remains unknown. Here, we report the discovery o...

Lentivirus-mediated gene transfer to the central nervous system: therapeutic and research applications.

The management of disorders of the nervous system remains a medical challenge. The key goals are to understand disease mechanisms, to validate therapeutic targets, and to develop new therapeutic strategies. Viral vector-mediated gene transfer can meet these goals and vectors based on lentiviruses have particularly useful features. Lentiviral vectors can deliver 8 kb of sequence, they mediate ge...

Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study

BACKGROUND Increasing evidences indicate that an unbalance between tryptases and their endogenous inhibitors, leading to an increased proteolytic activity, is implicated in the pathophysiology of rheumatoid arthritis. The aim of the present study was to evaluate the impact of tryptase inhibition on experimental arthritis. METHODS Analysis of gene expression and regulation in the mouse knee jo...